The It Ain't Magic Science Blog

Sphingolipid S1P: Potential new target for schizophrenia treatment

Sphingolipid S1P is reduced in brain white matter of people with schizophrenia, making S1P receptors a good target for new treatments.

Gut bacteria reduces insulin resistance, protects against diabetes

Scientists discover gut bacteria that reduce insulin resistance in your body and sugar in your poo.

Diazoxide pills for Alzheimer’s disease?

Drug therapy with with diazoxide relieved symptoms of Alzheimer’s disease in the brains of mice and improved memory.

Plant hormone combats dehydration

Scientists show that CLE25 is a plant hormone that travels from roots to leaves and helps close stomata in times of dehydration stress.

Nanocarrier spray: better crops without genetic modification

Gene expression, but not genomes, altered in plants and crops with a spray containing bioactive molecules tethered to nanocarrier peptides

Massive filaments, galaxies, and supermassive black holes

Big telescopes yield big data! Detailed observations gas filaments connecting galaxies in a distant proto-cluster in the early Universe.

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Latest research animations

Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

Latest Posts

Sep

27

AI used to detect fetal heart problems

AI used to detect fetal heart problems

by masataka sasabe | News

Researchers have developed a novel system that can automatically detect abnormalities in fetal hearts in real-time using artificial intelligence (AI). ???❤️

Sep

7

Protostars that exhibit large diversity in organic compounds

Protostars that exhibit large diversity in organic compounds

by riken research highlights | Research Highlight

A survey of a molecular cloud has found that the organic chemical makeup of protostars varies considerably.

Sep

6

Scientists solve epigenetic barriers to cloning

Scientists solve epigenetic barriers to cloning

by jens wilkinson | Hot Off the Press

Scientists show that two epigenetic factors improve the success rate of cloning via somatic cell nuclear transfer.

Aug

31

Transgenic plants ??on acid survive without water

Transgenic plants ??on acid survive without water

by adam phillips | Featured, Research Highlight

Scientists designed transgenic plants that survive drought-like conditions by bumping up acetic acid production only when water is scarce.

Aug

29

Two genes that regulate how much we dream

Two genes that regulate how much we dream

by masataka sasabe | Hot Off the Press

An international research team led by RIKEN BDR has identified a pair of genes that regulate how much REM (dream) and non-REM sleep an animal experiences.

Aug

3

Flies use fecal deposits as pheromones

Flies use fecal deposits as pheromones

by amanda alvarez | Hot Off the Press

Bioluminescence imaging of fly brains reveals neurons sensitive to fly poo laced with pheromones (you can see the fecal “landmark” in the dotted circle). Need we say more?

Jul

30

Hippocampal memory isn’t all about place cells

Hippocampal memory isn’t all about place cells

by amanda alvarez | Hot Off the Press

Scientists have found evidence that hippocampal memories of experience are not stored in place cells.

Jul

5

Summer fun: how plants beat the heat

Summer fun: how plants beat the heat

by adam phillips | Hot Off the Press

Scientists have discovered a gene that allows plants to cope with extreme heat by changing the composition of chloroplast membranes.

Jun

28

Freedom from fear ?‍♀️

Freedom from fear ?‍♀️

by adam phillips | Hot Off the Press

Researchers discover a dopaminergic circuit in the brain that allows fear associations to disappear when there isn’t anything to be afraid of anymore.

Jun

19

Blue gene regulation helps plants respond properly to light

Blue gene regulation helps plants respond properly to light

by adam phillips | Hot Off the Press

Blue light alters some gene expression in plants by changing the transcription start sites to downstream locations.

Jun

15

Out on a limb: the many ‘brains’ of the octopus

Out on a limb: the many ‘brains’ of the octopus

by amanda alvarez | Drop of science

Learn how (neurologically) cool octopus arms are (as if you didn’t already know).

Jun

12

Mutation links bipolar disorder to mitochondrial disease

Mutation links bipolar disorder to mitochondrial disease

by amanda alvarez | Hot Off the Press

ANT1 mutations found in bipolar disease that affect mitochondria lead to hyperexcitable serotonergic neuronal activity in the brain.

Jun

5

My science communication journey in Tokyo

My science communication journey in Tokyo

by sarah naimi | What's Up With Us

New contributor and nuclear physicist Sarah Naimi talks about her recent experience in science communication at a recent scicom event in Tokyo.

Jun

5

Gene linked to intellectual ability affects memory replay in mice

Gene linked to intellectual ability affects memory replay in mice

by adam phillips | Hot Off the Press

Scientists have discovered a gene in mice that allows memory replay at rest, a process necessary for forming long-lasting memories in mice.

May

30

Quick, call Spiderman: scientists discover how spider silk is formed

Quick, call Spiderman: scientists discover how spider silk is formed

by jens wilkinson | Hot Off the Press

A group of scientists led by researchers have discovered a key mechanism through which spider silk is formed.

May

16

Mutation protects against Alzheimer’s disease in mice

Mutation protects against Alzheimer’s disease in mice

by adam phillips | Hot Off the Press

Scientists discover a deletion mutation that reduces amyloid-beta plaque formation in Alzheimer’s disease model mice.

May

15

Plant peptide spells relief from salty stress

Plant peptide spells relief from salty stress

by adam phillips | Hot Off the Press

Newly discovered plant peptide hormone can be used to protect plants from excessive environmental salt.

May

14

Putting E. coli to work for us

Putting E. coli to work for us

by riken research highlights | Research Highlight

Specially engineered bacteria can produce an industrially significant chemical from renewable sources in a much gentler process than the one currently used by industry.

Apr

9

Why being sick can create anxiety

Why being sick can create anxiety

by riken research highlights | Research Highlight

Researchers have linked changes in mouse immune-cell metabolism to anxiety-related behavior and alterations in brain chemistry.

Apr

6

Plant hormone combats dehydration

Plant hormone combats dehydration

by adam phillips | Hot Off the Press

Scientists show that CLE25 is a plant hormone that travels from roots to leaves and helps close stomata in times of dehydration stress.

Mar

9

Heat shock system helps dried up bug come back to life

Heat shock system helps dried up bug come back to life

by jens wilkinson | Hot Off the Press

An international collaboration has determined that cooption of the Heat Shock Factor (HSF) gene system is what allows larvae of the sleeping chironomid to be able to survive severe desiccation.

Feb

23

In living color: imaging the brain with synthetic bioluminescence

In living color: imaging the brain with synthetic bioluminescence

by amanda alvarez | Hot Off the Press

A new way to image the brain from outside the head using bioluminescence.

Feb

9

Deep-brain exploration with nanomaterials

Deep-brain exploration with nanomaterials

by amanda alvarez | Hot Off the Press

A new way to optogenetically activate neurons deep in the brain using infrared light and upconversion nanoparticles. It’s non-invasive!

Feb

7

Running away from carbon dioxide: the terminal connection

Running away from carbon dioxide: the terminal connection

by adam phillips | Hot Off the Press

Even fish want to avoid carbon dioxide. Now we know that they can because of chemosensation and the Terminal Nerve.

Jan

19

Rainbow engineering to make the brain glow

Rainbow engineering to make the brain glow

by amanda alvarez | Drop of science

Bar talk about tinkering with bioluminescent molecules from jellyfish, corals, and algae, figuring out how they work, and making them more useful for brain science.

Jan

18

Geostationary satellite enables better precipitation and flood predictions

Geostationary satellite enables better precipitation and flood predictions

by jens wilkinson | Hot Off the Press

Data from the Himawari-8 geosynchronous satellite was used in weather simulations to improve forecasts of sudden precipitation and tropical storm development.

Jan

17

Clean and green: a moss that removes lead (Pb) from water

Clean and green: a moss that removes lead (Pb) from water

by adam phillips | Hot Off the Press

Scientists show that the moss Funaria hygrometrica can remove harmful lead from water when in the protonema stage of development.

Jan

15

The brain’s GPS has a buddy system

The brain’s GPS has a buddy system

by amanda alvarez | Hot Off the Press

In addition to encoding self location, brain cells in the rat hippocampus act like a GPS that encodes the location of other rats.

Dec

25

Leaky plants bad for drought resistance

Leaky plants bad for drought resistance

by adam phillips | Research in Depth

The KAI2 receptor for compounds found in smoke helps plants retain water and survive during drought.

Dec

22

Helping the body clock keep its cool

Helping the body clock keep its cool

by riken research highlights | Research Highlight

Two parallel temperature-responsive mechanisms ensure that circadian rhythms are not skewed by changes in temperature

Dec

21

The stars align

The stars align

by amanda alvarez | Drop of science

The stars align. That’s what you say, when things work out perfectly. In the case of an eclipse, of course, it’s not stars that align but rather the moon and sun.

Dec

7

What’s that smell? The advantage of sniffing

What’s that smell? The advantage of sniffing

by adam phillips | Hot Off the Press

Rhythmic sniffing boosts phase-coded neuronal signals in the mouse olfactory bulb that allow odors to be identified.

Nov

27

Quantum dots light up cancer with a little help

Quantum dots light up cancer with a little help

by riken research highlights | Research Highlight

Researchers have found a small connecting protein that can help make quantum dot-based probes for biomedical imaging.

Nov

24

Most precise measurement ever of proton magnetic moment

Most precise measurement ever of proton magnetic moment

by jens wilkinson | Hot Off the Press

Using a sophisticated setup, scientists have made the most precise measurement to date of the proton magnetic moment.

Nov

9

Proton and antiproton still seem identical

Proton and antiproton still seem identical

by jens wilkinson | Hot Off the Press

Using a novel two-particle measurement method, scientists have measured the magnetic moment of the antiproton at a precision 350 times higher than any previous measurement.

Nov

4

Microcolumns: elementary neuronal units that carpet the (mouse) brain

Microcolumns: elementary neuronal units that carpet the (mouse) brain

by amanda alvarez | Hot Off the Press

A hexagonal lattice organizes major cell types in the cerebral cortex, with similar cells synchronizing their activity in microcolumns.

Oct

24

Jupiter’s volcano-powered auroral lights

Jupiter’s volcano-powered auroral lights

by riken research highlights | Research Highlight

A collaborative effort used data from NASA’s Juno spacecraft to explain the transient auroras found on Jupiter.

Oct

13

Hepatoma (liver cancer) blocked by a sugar look-a-like

Hepatoma (liver cancer) blocked by a sugar look-a-like

by adam phillips | Hot Off the Press

A sugar (fucose) analog can prevent liver cancer (hepatoma) from invading healthy liver cells.

Oct

3

Random movements help color-detecting cells form the proper pattern

Random movements help color-detecting cells form the proper pattern

by jens wilkinson | Hot Off the Press

Scientists have used a mathematical model to explain why zebrafish cone cells in the eye are arranged in a specific pattern in all individuals.

Dietary amino acid linked to cancer in flies

Researchers have found a dietary amino acid linked to oncogene expression / tumor formation; reduced consumption reduced cancer in flies.

COVID-19: Changing the way we do research

COVID-19 series — Part #4: Team Leader Aki Minoda from RIKEN IMS talks about how the pandemic has affected the way we work.

Promising mouse model for Ngly1 deficiency

A recent study of Ngly1 deficient mice used a secondary knockout to create double knockouts with symptoms similar to human NGLY1 deficiency.

Gene regulator that allows plant rehydration after drought

New genetic insights into the plant rehydration process: this is why your plants don’t die after you forgot to water them.

Cassava engineered to produce healthier tapioca starch

Reducing the amount of starch branching enzymes in cassava plants made more resistant and thus healthier tapioca starch.

Zebrafish imagine a danger-free future to avoid threats in virtual reality

By imaging the brain while zebrafish “swim” in virtual reality, scientists have learned that even fish can create internal models to predict future outcomes.

Sep

20

Laser melting ice-core sampler for studying climate change

Laser melting ice-core sampler for studying climate change

by adam phillips | Hot Off the Press

This laser melting ice core sampler can determine temperature changes thousands of years ago on very fine timescale.

Aug

31

Gut bacteria reduces insulin resistance, protects against diabetes

Gut bacteria reduces insulin resistance, protects against diabetes

by adam phillips | Hot Off the Press

Scientists discover gut bacteria that reduce insulin resistance in your body and sugar in your poo.

Aug

23

Scary places burned into our minds by constant memory replay

Scary places burned into our minds by constant memory replay

by riken research highlights | Research Highlight

Researchers discover the mechanism through which places associated with negative experiences are burned into our memories.

Aug

18

Toward human hibernation: cold-resistant mouse stem cells

Toward human hibernation: cold-resistant mouse stem cells

by adam phillips | Hot Off the Press

Cold-resistant stem cells from “deep torpor” mice are a big step toward understanding why tissue survives hibernation.

Aug

15

A researcher’s journey part 2: emotional memory and being human

A researcher’s journey part 2: emotional memory and being human

by adam phillips | Interviews

Joshua Johansen from RIKEN CBS explains emotional memory, what his lab is doing, and what makes a good researcher.

Aug

8

Mathematical model predicts self-organized learning in real neurons

Mathematical model predicts self-organized learning in real neurons

by adam phillips | Hot Off the Press

The free energy principle predicted how real neural connections changed as neurons “learned” in a dish.

Aug

7

Deadly fungi beaten with fatty acid synthase inhibitor

Deadly fungi beaten with fatty acid synthase inhibitor

by adam phillips | Hot Off the Press

A new approach to attacking fungi involves inhibiting a gene needed for making fatty acids.

Jul

12

A new and improved way to store hydrogen

A new and improved way to store hydrogen

by masataka sasabe | Hot Off the Press

A simple chemical reaction allows hydrogen-carrying ammonia to be stored and retrieved cheaply and easily.

Jun

29

A new alpha-particle treatment for multiple cancers

A new alpha-particle treatment for multiple cancers

by adam phillips | Hot Off the Press

A new type of alpha-particle therapy allows selective targeting of tumors in multiple cancers.

Social contact-seeking behavior and loneliness in the brain

Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

Artificial gravity protects the immune system of mice in space

Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.

Transgenic plants ??on acid survive without water

Scientists designed transgenic plants that survive drought-like conditions by bumping up acetic acid production only when water is scarce.

Next stop: clinical hair regeneration

A new recipe for continuous cyclical hair regeneration in mice. This means that the hair will continue to fall out and regrow like normal hair.

Apr

22

Eco-friendly ammonia production for fertilizers and alternative fuel

Eco-friendly ammonia production for fertilizers and alternative fuel

by adam phillips | Hot Off the Press

A new process that allows ammonia to be produced using much less energy than the standard methods.

Apr

11

Cubes of brain tissue allow drug discovery without animals

Cubes of brain tissue allow drug discovery without animals

by masataka sasabe | Hot Off the Press

Modeling the blood-brain-barrier with brains-in-a-cube allows drug testing without the need for animals.

Apr

3

Gut bacteria could help overcome milk allergy

Gut bacteria could help overcome milk allergy

by adam phillips | Hot Off the Press

Analysis shows that some gut bacteria could help improve oral immunotherapy against milk allergy.

Apr

2

Detecting pathogens: the evolution of plant immunity

Detecting pathogens: the evolution of plant immunity

by masataka sasabe | Hot Off the Press

Scientists find recognition receptors for plant growth and plant immunity that share a common evolutionary origin.

Mar

21

Genomic “butterfly effect” involving TADs explains risk for autism

Genomic “butterfly effect” involving TADs explains risk for autism

by masataka sasabe | Hot Off the Press

De novo mutations in three-dimensional structures in the genome containing known ASD genes were found to be associated with ASD risk.

Mar

19

Heat used to transform antiskyrmions to skyrmions and back

Heat used to transform antiskyrmions to skyrmions and back

by jens wilkinson | Hot Off the Press

Scientists discover a way to transform antiskyrmions to skyrmions and back using heat and magnetic fields.