Microcolumns: elementary neuronal units that carpet the (mouse) brain


A hexagonal lattice organizes major cell types in the cerebral cortex, with similar cells synchronizing their activity in microcolumns.

Skipping fatty acids could be recipe for schizophrenia


Prenatal lack of omega-3 and omega-6 fatty acids linked to epigenetic changes that lead to schizophrenic symptoms in mice.

Mutations, CRISPR, and spinocerebellar ataxia


Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

Dopamine reduces beta-amyloid plaques in Alzheimer’s disease


Increasing dopamine in the brains of AD model mice led to increased neprilysin, which broke down amyloid-beta plaques and improved memory.

Nanocarrier spray: better crops without genetic modification


Gene expression, but not genomes, altered in plants and crops with a spray containing bioactive molecules tethered to nanocarrier peptides

Strong emotions plus non-REM sleep equals longer-lasting perceptual memories


Perceptual memories linked to positive emotions, such as joy or happiness, are strengthened during sleep, specifically during periods of deep non-REM sleep.

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Dec

21

The stars align

The stars align


The stars align. That’s what you say, when things work out perfectly. In the case of an eclipse, of course, it’s not stars that align but rather the moon and sun.

Learning and unlearning to fear: The two faces of noradrenaline


Fear association and unlearning fear association require different populations of noradrenaline neurons in the locus coeruleus.

Consciousness, brain connections, and the claustrum


Research shows that the claustrum acts as a ‘consciousness conductor’ that synchronizes and connects areas within the mouse brain.

Ultraprecise clocks and the Tokyo Skytree verify Einstein’s theory of relativity


Time measured at the top and bottom of the Tokyo Skytree with ultraprecise clocks has verified the time dilation effect predicted by Einstein.

Cubes of brain tissue allow drug discovery without animals


Modeling the blood-brain-barrier with brains-in-a-cube allows drug testing without the need for animals.

Engineering crop immunity from a receptor in pomelo fruit


Synthetic receptors derived from the pomelo fruit can help crops become immune to thousands of pathogens.

Zebrafish imagine a danger-free future to avoid threats in virtual reality


By imaging the brain while zebrafish “swim” in virtual reality, scientists have learned that even fish can create internal models to predict future outcomes.

Social contact-seeking behavior and loneliness in the brain


Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

Eating a high fat diet without getting obese?


Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Artificial gravity protects the immune system of mice in space


Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.

Diazoxide pills for Alzheimer’s disease?


Drug therapy with with diazoxide relieved symptoms of Alzheimer’s disease in the brains of mice and improved memory.