The It Ain't Magic Science Blog

New metalloenzyme system selectively targets cancer cells

Specific targeting of cancer cells and onsite drug synthesis has been achieved using a new artificial metalloenzyme delivery system.

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Gut bacteria reduces insulin resistance, protects against diabetes

Scientists discover gut bacteria that reduce insulin resistance in your body and sugar in your poo.

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Solar cells you can put in the wash

Scientists have developed ultra-thin photovoltaic solar cells that can be incorporated into fabric and even washed.

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Consciousness, brain connections, and the claustrum

Research shows that the claustrum acts as a ‘consciousness conductor’ that synchronizes and connects areas within the mouse brain.

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Trigger region found for epileptic absence seizures

A mouse model shows that absence seizures are triggered by faulty connections between the cortex and fast-spiking neurons in the striatum.

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A faster and more sensitive antibody test for COVID-19

Fast and sensitive: A new antibody test for the COVID-19 virus. Just a pinprick of blood and results in 30 minutes.

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Topics

Latest research animations

Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

Latest Posts

Feb

Social contact-seeking behavior and loneliness in the brain

by adam phillips | Featured, Hot Off the Press

Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

Feb

New treatment assembles cancer drug inside the body

by masataka sasabe | Featured, Hot Off the Press

Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

Jan

New lab-grown retinal sheets almost ready for clinical trials

by adam phillips | Featured, Hot Off the Press

A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.

Jan

The free-energy principle explains neural network behavior

by adam phillips | Hot Off the Press

Scientists show that the free-energy principle can explain how neural networks work.

Jan

How does gravity affect antimatter?

by jens wilkinson | Featured, Hot Off the Press

Scientists find that antimatter reacts to gravity the same way that regular matter does.

Dec

Super-thin wearable electronics just got more flexible

by adam phillips | Featured, Hot Off the Press

A method for making super-flexible and ultra-thin wearable electronics uses water-vapor plasma to create gold-gold bonds.

Dec

Cassava engineered to produce healthier tapioca starch

by adam phillips | Hot Off the Press

Reducing the amount of starch branching enzymes in cassava plants made more resistant and thus healthier tapioca starch.

Dec

Diazoxide pills for Alzheimer’s disease?

by adam phillips | Featured, Hot Off the Press

Drug therapy with with diazoxide relieved symptoms of Alzheimer’s disease in the brains of mice and improved memory.

Oct

Zebrafish imagine a danger-free future to avoid threats in virtual reality

by admin | Hot Off the Press

By imaging the brain while zebrafish “swim” in virtual reality, scientists have learned that even fish can create internal models to predict future outcomes.

Sep

Kleefstra syndrome in mice reversed after birth

by adam phillips | Hot Off the Press

Researchers used a postnatal supply of GLP to reverse neural and behavioral symptoms of Kleefstra syndrome in mice!

Sep

A faster and more sensitive antibody test for COVID-19

by masataka sasabe | Hot Off the Press

Fast and sensitive: A new antibody test for the COVID-19 virus. Just a pinprick of blood and results in 30 minutes.

Jul

Opossums are the first genome edited marsupials

by masataka sasabe | Featured, Hot Off the Press

A new piezoelectronic microinjection method has allowed the first successful genome editing in marsupials: albino opossums.

Jul

Methylation mutation directly linked to autism

by adam phillips | Hot Off the Press

A mutation in a gene needed for H3K9 methylation is directly linked to autism spectrum disorders and early neurodevelopment.

Jun

Melatonin in mice, circadian rhythms, and daily torpor

by admin | Hot Off the Press

A new breed of lab mouse allows the study of naturally occurring melatonin. These mice will adjust better to jetlag than regular lab mice and experience daily torpor.

Jun

Why (mouse) mothers take risks to protect their infants

by adam phillips | Featured, Hot Off the Press

The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.

May

Dietary amino acid linked to cancer in flies

by masataka sasabe | Hot Off the Press

Researchers have found a dietary amino acid linked to oncogene expression / tumor formation; reduced consumption reduced cancer in flies.

Apr

Cancer cells killed with artificial glycosylated metalloenzyme

by adam phillips | Hot Off the Press

Scientists have developed two cancer therapies that use an artificial glycosylated metalloenzyme to specifically target cancer cells in mice.

Apr

H2AK119ub1: How you inherit acquired traits from your mom

by adam phillips | Featured, Hot Off the Press

H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.

Apr

COVID-19: Changing the way we do research

by jens wilkinson | Interviews

COVID-19 series — Part #4: Team Leader Aki Minoda from RIKEN IMS talks about how the pandemic has affected the way we work.

Mar

Telework: a societal game-changer

by jens wilkinson | Interviews

COVID-19 series — installment #3: Team Leader Osamu Sakura (@RIKEN Center for Advanced Intelligence Project) talks about how the pandemic has affected society through the need for telework.

Mar

Decision-making during the COVID-19 pandemic

by jens wilkinson | Interviews

COVID-19 series — installment #2: RIKEN CBS Unit Leader Rei Akaishi talks about government decision-making during the pandemic.

Mar

Confronting a string of epidemics including COVID-19

by jens wilkinson | Interviews

COVID-19 series — installment #1: RIKEN Executive Director Shigeo Koyasu talks about epidemics and what a good response looks like.

Feb

Next stop: clinical hair regeneration

by adam phillips | Featured, Hot Off the Press

A new recipe for continuous cyclical hair regeneration in mice. This means that the hair will continue to fall out and regrow like normal hair.

Jan

Godzilla-sized zooplankton for better aquafarming

by masataka sasabe | Hot Off the Press

Scientists have created extra large zooplankton to help feed the fish in aquafarms. The new plankton were created using an ion beam to generate mutations.

Dec

Electric rays to help us map the ocean floor

by adam phillips | Hot Off the Press

Electric rays and sting rays could map the ocean floor through their natural behavior, helping us find resources and collect data on other ocean life.

Nov

Bacterial drug resistance studied by robotic E. coli evolution

by masataka sasabe | Hot Off the Press

Experimentally evolving E. coli under pressure from a large number of antibiotics was able to identify constraints underlying evolved drug resistance.

Nov

New artificial skin helps avoid animal testing

by masataka sasabe | Hot Off the Press

A new artificial skin that reproduces proper tension can be used to research skin function and disease while reducing the need to experiment on animals.

Oct

Social novelty in the brain: haven’t I seen you someplace before?

by adam phillips | Hot Off the Press

Social novelty and contextual novelty are segregated in the SuM region of the hypothalamus and in projections to the hippocampus, allowing memories of meeting new people to be formed separately from memories of new places.

Sep

FABP4: A preschool-aged biomarker for autism

by adam phillips | Hot Off the Press

Reduced FABP4 was found in preschool-aged children with autism spectrum disorder, making it a potential new biomarker for the condition.

Sep

Microbial infections are a parasitic plant’s dream

by adam phillips | Hot Off the Press

Parasitic plants use quinones produced by their host to attack. Now we know that crops produce quinones as an immune response against microbial infection. How can we protect crops from both kinds of attack?

Aug

Gut bacteria double team worsens symptoms of multiple sclerosis

by adam phillips | Hot Off the Press

Joint activity of two gut bacteria leads to excessive MOG-specific T-cell activity and demyelination of neurons in the spinal cord of a mouse model of multiple sclerosis.

Aug

Something smells fishy: categorizing odors in the brain

by masataka sasabe | Hot Off the Press

Calcium imaging and mathematical model explain how categories and mixtures of odors are represented in the fly brain and consistent across individual flies.

Jul

Photosynthetic bacteria spin spider silk for the masses

by masataka sasabe | Hot Off the Press

A little genetic engineering and a special recipe allows photosynthetic bacteria to mass-produce super lightweight spider silk for use in manufacturing.

Jun

Blood cell mutations linked to leukemia are inevitable

by adam phillips | Hot Off the Press

Researchers show that blood cell mutations increase with age identify risk factors for developing leukemia in Japanese and European populations.

Jun

Organic nitrogen in soil helps crop growth

by jens wilkinson | Hot Off the Press

Scientists used a multi-omics analysis to show that soil solarization helps crops grow because it increases organic nitrogen in the soil.

May

Consciousness, brain connections, and the claustrum

by admin | Hot Off the Press

Research shows that the claustrum acts as a ‘consciousness conductor’ that synchronizes and connects areas within the mouse brain.

May

A new imaging biomarker for the aging brain

by adam phillips | Hot Off the Press

Enlarged ventricles is a sign of an aging brain. New research shows that this phenomenon can be predicted by lagging brain circulation that is detected by MRI.

Apr

Sphingolipid S1P: Potential new target for schizophrenia treatment

by adam phillips | Hot Off the Press

Sphingolipid S1P is reduced in brain white matter of people with schizophrenia, making S1P receptors a good target for new treatments.

Apr

Staining that lights up whole organs and bodies

by masataka sasabe | Hot Off the Press

Scientists have developed a staining procedure that makes see-through tissue, organs, and bodies useful.

Talking science Illustration with Misaki Ouchida

Whether it’s bird anatomy or science cartoons, Masaki Ouchida can do it all. She spoke with us about her career in science illustration, from the US to Japan.

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Atlas of the aging lipidome highlights kidneys and gut bacteria

The atlas revealed sex differences in the aging kidney lipidome and lipid byproducts of gut bacteria that accumulate throughout the body.

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Opto-OISI: imaging connections in the living brain

A new imaging technique called opto-OISI allows scientists to non-invasively visualize where specific neurons project in the living brain.

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Implantable blastocyst‐like cysts grown from stem cells

Embryo Organoids?! Blastocyst‐like cysts grown from pluripotent mouse stem cells were similar to natural blastocysts (early embryos).

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Freedom from fear ?‍♀️

Researchers discover a dopaminergic circuit in the brain that allows fear associations to disappear when there isn’t anything to be afraid of anymore.

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Supermassive black holes still dark and mysterious

For the first time, scientists have measured the strength of magnetic fields near supermassive black holes and something doesn’t add up.

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Aug

Predictive grid cells help self navigation in the brain

by adam phillips | Hot Off the Press

Scientists have discovered grid cells in the brain that map an animal’s (or human’s) future position in space.

Aug

Dopamine reduces beta-amyloid plaques in Alzheimer’s disease

by adam phillips | Hot Off the Press

Increasing dopamine in the brains of AD model mice led to increased neprilysin, which broke down amyloid-beta plaques and improved memory.

Jul

RIKEN discovers new T cells related to immune disorders

by adam phillips | Hot Off the Press

Immune-related diseases like multiple sclerosis associated with genetic variation in newly discovered, rare T cells.

Jul

Will the “love hormone” ever be used to treat a rare genetic disease?

by masataka sasabe | Drop of science, What's Up With Us

One of the pitfalls of researching an extremely rare disease: getting enough data to support clinical trials could be impossible.

Jun

Purple biomass makes a good crop fertilizer

by adam phillips | Hot Off the Press

Biomass made from purple marine bacteria provides more than enough nitrogen to plants without harming the environment

Jun

Atlas of the aging lipidome highlights kidneys and gut bacteria

by masataka sasabe | Hot Off the Press

The atlas revealed sex differences in the aging kidney lipidome and lipid byproducts of gut bacteria that accumulate throughout the body.

May

Root growth improved in soil contaminated with cesium

by masataka sasabe | Hot Off the Press

Overactivating the ABA signaling pathway in plants prevented cesium in soil from blocking root growth in plants.

May

Japanese people are a mixture of three separate ancestral groups

by jens wilkinson | Hot Off the Press

A new study shows that the current Japanese population is derived from 3 ancestral groups, one of which brought Denisovan DNA to the party.

May

Space Café Tokyo explains sus sci-fi media

by kelly | What's Up With Us

Our very own Kelly writes about how much fun she had at Space Café Tokyo. Softcore science and beer.

Diazoxide pills for Alzheimer’s disease?

Drug therapy with with diazoxide relieved symptoms of Alzheimer’s disease in the brains of mice and improved memory.

Read on

Why (mouse) mothers take risks to protect their infants

The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.

Read on

Eating a high fat diet without getting obese?

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

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Artificial gravity protects the immune system of mice in space

Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.

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Dec

Scientists develop new and improved quantum gates

by jens wilkinson | Hot Off the Press

High-fidelity, low error quantum gates allow more reliable and accurate quantum computations, making the future of quantum computers more promising.

Dec

Nanopores in deep-sea hydrothermal vents and the origin of life

by adam phillips | Hot Off the Press

“Naturally occurring selective nanopore ion channels in deep-sea hydrothermal vents are similar to ion channels found in cells and could help explain the origin of life.