The It Ain't Magic Science Blog

The free-energy principle explains neural network behavior

Scientists show that the free-energy principle can explain how neural networks work.

Strong emotions plus non-REM sleep equals longer-lasting perceptual memories

Perceptual memories linked to positive emotions, such as joy or happiness, are strengthened during sleep, specifically during periods of deep non-REM sleep.

Methylation mutation directly linked to autism

A mutation in a gene needed for H3K9 methylation is directly linked to autism spectrum disorders and early neurodevelopment.

Freedom from fear ?‍♀️

Researchers discover a dopaminergic circuit in the brain that allows fear associations to disappear when there isn’t anything to be afraid of anymore.

Random movements help color-detecting cells form the proper pattern

Scientists have used a mathematical model to explain why zebrafish cone cells in the eye are arranged in a specific pattern in all individuals.

Brain tissue kept alive for weeks with new microfluidic device

A new microfluidic device can keep tissue cultures functional for weeks on an artificial membrane

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Latest research animations

Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

Latest Posts

Mar

20

Low-protein diet changes sperm and health of future offspring

Low-protein diet changes sperm and health of future offspring

by masataka sasabe | Hot Off the Press

Low-protein diets in male mice alter sperm and result in offspring that have metabolic problems like diabetes in adulthood.

Mar

13

Physiological origami and proper body development in flies

Physiological origami and proper body development in flies

by masataka sasabe | Hot Off the Press

Genetics and mechanical origami in the fly embryo helps proper body development by fighting off “noisy” fluctuations is the environment.

Mar

11

Efficient and durable ultra-thin solar cells

Efficient and durable ultra-thin solar cells

by jens wilkinson | Hot Off the Press

Ultra-thin, flexible, organic solar cells that degrade less than 5 percent after 3,000 hours and an energy conversion ratio of 13%.

Mar

9

Tape and vermilion: ingredients for mapping artifact origins

Tape and vermilion: ingredients for mapping artifact origins

by adam phillips | Hot Off the Press

Vermilion samples taken from ancient artifacts with sulfur-free tape can tell us about trade patterns 3000 years ago.

Jan

29

Are you “at risk” of being a habitual coffee drinker?

Are you “at risk” of being a habitual coffee drinker?

by adam phillips | Hot Off the Press

Several single nucleotide polymorphisms (SNPs) are related to dietary habits, including coffee, tea, tofu, and yogurt consumption.

Jan

24

Astrocytes powered by norepinephrine during fear-memory formation

Astrocytes powered by norepinephrine during fear-memory formation

by admin | Hot Off the Press

Norepinephrine released in the locus coeruleus during fear learning is accompanied by increased calcium and cAMP levels in nearby astrocytes.

Dec

19

Brain wave synchrony can predict memory age

Brain wave synchrony can predict memory age

by admin | Hot Off the Press

The degree of neuronal synchrony between the anterior cingulate cortex and the hippocampus during recall is an indication of memory age (in mice).

Dec

18

AI identifies features associated with cancer recurrence

AI identifies features associated with cancer recurrence

by masataka sasabe | Hot Off the Press

Artificial intelligence has successfully identified features relevant to cancer prognosis that were not previously noted by pathologists

Nov

15

Longevity in supercentenarians linked to cytotoxic T-cells

Longevity in supercentenarians linked to cytotoxic T-cells

by jens wilkinson | Hot Off the Press

Blood analysis in supercentenarians showed that they have many more cytotoxic CD4 T-cells than people with average life spans.

Oct

29

Schizophrenia biomarker (hydrogen sulfide) in human hair

Schizophrenia biomarker (hydrogen sulfide) in human hair

by adam phillips | Hot Off the Press

Not only is hydrogen sulfide a good biomarker for schizophrenia, it’s also the culprit and a new starting point for drug discovery.

Oct

10

Brain tissue kept alive for weeks with new microfluidic device

Brain tissue kept alive for weeks with new microfluidic device

by adam phillips | Hot Off the Press

A new microfluidic device can keep tissue cultures functional for weeks on an artificial membrane

Oct

4

Massive filaments, galaxies, and supermassive black holes

Massive filaments, galaxies, and supermassive black holes

by jens wilkinson | Hot Off the Press

Big telescopes yield big data! Detailed observations gas filaments connecting galaxies in a distant proto-cluster in the early Universe.

Oct

3

Understanding non-coding DNA: gene “enhancers”

Understanding non-coding DNA: gene “enhancers”

by jens wilkinson | Hot Off the Press

NETCAGE is a newly developed technique for determining the structure of portions of the non-coding genome called ‘enhancers.’

Aug

22

Mini-EUSO launched to the International Space Station ?

Mini-EUSO launched to the International Space Station ?

by jens wilkinson | News

The Mini-EUSO observatory was successfully launched to the International Space Station aboard the Soyuz MS14! NASA video inside!

Aug

9

Implantable blastocyst‐like cysts grown from stem cells

Implantable blastocyst‐like cysts grown from stem cells

by adam phillips | Hot Off the Press

Embryo Organoids?! Blastocyst‐like cysts grown from pluripotent mouse stem cells were similar to natural blastocysts (early embryos).

Jul

16

Talking science Illustration with Misaki Ouchida

Talking science Illustration with Misaki Ouchida

by adam phillips | Featured, Interviews, What's Up With Us

Whether it’s bird anatomy or science cartoons, Masaki Ouchida can do it all. She spoke with us about her career in science illustration, from the US to Japan.

Jul

9

Cyborg microchip valve driven by earthworm muscle

Cyborg microchip valve driven by earthworm muscle

by adam phillips | Hot Off the Press

This earthworm muscle-controlled biological microelectromechanical system (bio‐MEMS) could lead the way to next-generation medical implants.

Jul

3

Eating a high fat diet without getting obese?

Eating a high fat diet without getting obese?

by adam phillips | Featured, Hot Off the Press

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Jul

2

New metalloenzyme system selectively targets cancer cells

New metalloenzyme system selectively targets cancer cells

by masataka sasabe | Hot Off the Press

Specific targeting of cancer cells and onsite drug synthesis has been achieved using a new artificial metalloenzyme delivery system.

Jun

27

Boosting betaine may be a treatment for schizophrenia

Boosting betaine may be a treatment for schizophrenia

by admin | Hot Off the Press

Supplementing model mice with glycine betaine (trimethylglycine), a compound originally derived from beets, can alleviate symptoms of schizophrenia.

Jun

19

Gray matter volume links symptoms in autism

Gray matter volume links symptoms in autism

by adam phillips | Hot Off the Press

Low gray matter volume in the posterior superior parietal lobule (pSPL) was found to correlate with specific cognitive and perceptual symptoms of autism.

Jun

6

New mechanism allows lower energy requirement for OLED displays

New mechanism allows lower energy requirement for OLED displays

by jens wilkinson | Hot Off the Press

Scientists have found a way to significantly reduce the amount of energy required by organic light emitting diodes (OLED) displays.

Jun

6

CAPON links Alzheimer’s plaques to neurodegeneration

CAPON links Alzheimer’s plaques to neurodegeneration

by adam phillips | Hot Off the Press

CAPON was found to link Aβ plaques and hippocampal neurodegeneration in mice, explaining how these two hallmarks of Alzheimer’s disease are related.

May

20

AdR blockers protect the brain from stroke damage

AdR blockers protect the brain from stroke damage

by admin | Hot Off the Press

Treatment with adrenergic receptor antagonists (AdR blockers) was able to reduce stroke-related brain damage in mice and improve motor recovery.

Apr

25

Trigger region found for epileptic absence seizures

Trigger region found for epileptic absence seizures

by adam phillips | Hot Off the Press

A mouse model shows that absence seizures are triggered by faulty connections between the cortex and fast-spiking neurons in the striatum.

Apr

23

Opto-OISI: imaging connections in the living brain

Opto-OISI: imaging connections in the living brain

by admin | Hot Off the Press

A new imaging technique called opto-OISI allows scientists to non-invasively visualize where specific neurons project in the living brain.

Apr

19

Flies smell through a gore-tex system

Flies smell through a gore-tex system

by masataka sasabe | Hot Off the Press

The newly named gore-tex gene is responsible for the development of nanopores that allow chemicals in the air to be detected (in flies).

Apr

11

Protein pileup affects social behavior through altered brain signaling

Protein pileup affects social behavior through altered brain signaling

by admin | Hot Off the Press

When a normal cellular cleanup process is disrupted, social behavior in mice is disrupted and they start behaving in ways that resemble human symptoms of autism spectrum disorder and schizophrenia.

Mar

29

The joys of computational mass spectrometry

The joys of computational mass spectrometry

by adam phillips | Hot Off the Press

Scientists have developed a new automated computational mass spectrometry system that can search an organism’s entire metabolome for as-yet-unknown metabolites (potential drugs).

Mar

5

Pulses of light can enhance superconductivity

Pulses of light can enhance superconductivity

by jens wilkinson | Hot Off the Press

Pulses of light could be used to turn materials into superconductors through an unconventional type of superconductivity.

Feb

15

Scientists create new type of self-healing material

Scientists create new type of self-healing material

by jens wilkinson | Hot Off the Press

This newly created ethylene-based material has shape memory that allows self-healing!

Feb

12

Brain clock ticks differently in autism

Brain clock ticks differently in autism

by admin | Hot Off the Press

A new brain imaging study shows that autistic severity is linked to how long certain regions of the brain store information.

Dec

19

Supermassive black holes still dark and mysterious

Supermassive black holes still dark and mysterious

by jens wilkinson | Hot Off the Press

For the first time, scientists have measured the strength of magnetic fields near supermassive black holes and something doesn’t add up.

Dec

7

Evolution of the inner ear: insights from jawless fish

Evolution of the inner ear: insights from jawless fish

by adam phillips | Hot Off the Press

A new story for inner ear evolution based on the developmental patterning found in hagfish, one of two extant jawless vertebrates and a link to the last common ancestor of modern jawed vertebrates.

Dec

5

Tumor detection during breast cancer surgery

Tumor detection during breast cancer surgery

by jens wilkinson | Hot Off the Press

Scientists have developed a new way to accurately detect the margins between cancerous and non-cancerous tissue during breast cancer surgery.

Nov

26

Smarter AI: machine learning without negative data

Smarter AI: machine learning without negative data

by masataka sasabe | Hot Off the Press

Scientists have developed a new method for machine learning that allows an AI to make better classifications without negative data.

Nov

16

Nerdnite recap: When the brainbow met the boson

Nerdnite recap: When the brainbow met the boson

by admin | Drop of science

Fun times at nerdnite tokyo. Brains, bosons, and math, oh my!

Nov

13

Mutations, CRISPR, and spinocerebellar ataxia

Mutations, CRISPR, and spinocerebellar ataxia

by adam phillips | Hot Off the Press

Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

Nov

6

Gene regulator that allows plant rehydration after drought

Gene regulator that allows plant rehydration after drought

by adam phillips | Hot Off the Press

New genetic insights into the plant rehydration process: this is why your plants don’t die after you forgot to water them.

Simple but revolutionary modular organoids

A new way to construct complex 3D organoids without using elaborate techniques! The trick using modular cubes with hydrogel layers.

Skipping fatty acids could be recipe for schizophrenia

Prenatal lack of omega-3 and omega-6 fatty acids linked to epigenetic changes that lead to schizophrenic symptoms in mice.

Physiological origami and proper body development in flies

Genetics and mechanical origami in the fly embryo helps proper body development by fighting off “noisy” fluctuations is the environment.

Brain wave synchrony can predict memory age

The degree of neuronal synchrony between the anterior cingulate cortex and the hippocampus during recall is an indication of memory age (in mice).

Godzilla-sized zooplankton for better aquafarming

Scientists have created extra large zooplankton to help feed the fish in aquafarms. The new plankton were created using an ion beam to generate mutations.

New mechanism allows lower energy requirement for OLED displays

Scientists have found a way to significantly reduce the amount of energy required by organic light emitting diodes (OLED) displays.

Apr

24

Brainless memory makes the spinal cord smarter than previously thought

Brainless memory makes the spinal cord smarter than previously thought

by adam phillips | Hot Off the Press

The spinal cord learns how to direct limb muscles to avoid aversive sensations and recalls the memories using separate neural circuitry. Oh, and without a brain!

Apr

22

Eco-friendly ammonia production for fertilizers and alternative fuel

Eco-friendly ammonia production for fertilizers and alternative fuel

by adam phillips | Hot Off the Press

A new process that allows ammonia to be produced using much less energy than the standard methods.

Apr

11

Cubes of brain tissue allow drug discovery without animals

Cubes of brain tissue allow drug discovery without animals

by masataka sasabe | Hot Off the Press

Modeling the blood-brain-barrier with brains-in-a-cube allows drug testing without the need for animals.

Apr

3

Gut bacteria could help overcome milk allergy

Gut bacteria could help overcome milk allergy

by adam phillips | Hot Off the Press

Analysis shows that some gut bacteria could help improve oral immunotherapy against milk allergy.

Apr

2

Detecting pathogens: the evolution of plant immunity

Detecting pathogens: the evolution of plant immunity

by masataka sasabe | Hot Off the Press

Scientists find recognition receptors for plant growth and plant immunity that share a common evolutionary origin.

Mar

21

Genomic “butterfly effect” involving TADs explains risk for autism

Genomic “butterfly effect” involving TADs explains risk for autism

by masataka sasabe | Hot Off the Press

De novo mutations in three-dimensional structures in the genome containing known ASD genes were found to be associated with ASD risk.

Mar

19

Heat used to transform antiskyrmions to skyrmions and back

Heat used to transform antiskyrmions to skyrmions and back

by jens wilkinson | Hot Off the Press

Scientists discover a way to transform antiskyrmions to skyrmions and back using heat and magnetic fields.

Jan

23

Real webshooters? Synthetic spider silk spun from artificial gland

Real webshooters? Synthetic spider silk spun from artificial gland

by adam phillips | Hot Off the Press

Scientists create a microfluidic device that spins artificial spider silk from spidroins proteins, duplicating silk’s complex molecular structure.

Jan

15

Omics Omics Omics: Analysis predicts ovarian cancer-treating drug

Omics Omics Omics: Analysis predicts ovarian cancer-treating drug

by adam phillips | Hot Off the Press

Multi-omics analysis prediction: drugs that inhibit Ras signaling will help prevent tumor formation in serous ovarian cancer.

Next stop: clinical hair regeneration

A new recipe for continuous cyclical hair regeneration in mice. This means that the hair will continue to fall out and regrow like normal hair.

Opossums are the first genome edited marsupials

A new piezoelectronic microinjection method has allowed the first successful genome editing in marsupials: albino opossums.

Talking science Illustration with Misaki Ouchida

Whether it’s bird anatomy or science cartoons, Masaki Ouchida can do it all. She spoke with us about her career in science illustration, from the US to Japan.

New treatment assembles cancer drug inside the body

Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

Jul

8

RIKEN discovers new T cells related to immune disorders

RIKEN discovers new T cells related to immune disorders

by adam phillips | Hot Off the Press

Immune-related diseases like multiple sclerosis associated with genetic variation in newly discovered, rare T cells.

Jul

2

Will the “love hormone” ever be used to treat a rare genetic disease?

Will the “love hormone” ever be used to treat a rare genetic disease?

by masataka sasabe | Drop of science, What's Up With Us

One of the pitfalls of researching an extremely rare disease: getting enough data to support clinical trials could be impossible.

Jun

27

Purple biomass makes a good crop fertilizer

Purple biomass makes a good crop fertilizer

by adam phillips | Hot Off the Press

Biomass made from purple marine bacteria provides more than enough nitrogen to plants without harming the environment

Jun

20

Atlas of the aging lipidome highlights kidneys and gut bacteria

Atlas of the aging lipidome highlights kidneys and gut bacteria

by masataka sasabe | Hot Off the Press

The atlas revealed sex differences in the aging kidney lipidome and lipid byproducts of gut bacteria that accumulate throughout the body.

May

22

Root growth improved in soil contaminated with cesium

Root growth improved in soil contaminated with cesium

by masataka sasabe | Hot Off the Press

Overactivating the ABA signaling pathway in plants prevented cesium in soil from blocking root growth in plants.

May

17

Japanese people are a mixture of three separate ancestral groups

Japanese people are a mixture of three separate ancestral groups

by jens wilkinson | Hot Off the Press

A new study shows that the current Japanese population is derived from 3 ancestral groups, one of which brought Denisovan DNA to the party.