The It Ain't Magic Science Blog

A new imaging biomarker for the aging brain

Enlarged ventricles is a sign of an aging brain. New research shows that this phenomenon can be predicted by lagging brain circulation that is detected by MRI.

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Protein antigens in meat, milk, and other foods suppress gut tumors

Food antigens were found to prevent small intestinal tumors in gut-tumor prone mice by making ensuring we have enough T cells for defense.

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Stem cell exhaustion and proliferation: An aging fly’s tale

Blocking the gene ced-6 led to stem cell exhaustion in aging fruit flies and prevented repair of damaged intestines.

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Chromosome copying errors pinpointed in developing embryos

The DNA duplication process changes during embryogenesis and chromosome copying errors increase during the transition.

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Albumin drops medicine off at cancer site then leaves the body

By changing albumin’s identity, drugs can carried to their targets and then removed from the body after being used.

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Atlas of the aging lipidome highlights kidneys and gut bacteria

The atlas revealed sex differences in the aging kidney lipidome and lipid byproducts of gut bacteria that accumulate throughout the body.

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Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

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A new type of cell death discovered in fly guts

A completely unknown type of cell death called “erebosis” has been discovered in the guts of the common fruit fly.

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Crying baby? Science says walk, then sit

Recipe for success: Walk 5 min, sit 8 min, lay no-longer-crying baby down. Now you can relax.

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Kleefstra syndrome in mice reversed after birth

Researchers used a postnatal supply of GLP to reverse neural and behavioral symptoms of Kleefstra syndrome in mice!

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Something smells fishy: categorizing odors in the brain

Calcium imaging and mathematical model explain how categories and mixtures of odors are represented in the fly brain and consistent across individual flies.

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Robotic AI helps efficient growth of replacement organs

Humans team-up with a robotic AI to speed up experiments to find the best way to regrow damaged eye tissue from stem cells.

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From evolutionary morphology to Godzilla

I recently spoke with RIKEN scientist Shigeru Kuratani about evolutionary morphology, sci-fi monsters, the genius of Alien, and more.

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Jul

Cyborg microchip valve driven by earthworm muscle

by adam phillips | Hot Off the Press

This earthworm muscle-controlled biological microelectromechanical system (bio‐MEMS) could lead the way to next-generation medical implants.

Jul

Eating a high fat diet without getting obese?

by adam phillips | Featured, Hot Off the Press

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Jul

New metalloenzyme system selectively targets cancer cells

by masataka sasabe | Hot Off the Press

Specific targeting of cancer cells and onsite drug synthesis has been achieved using a new artificial metalloenzyme delivery system.

Jun

Boosting betaine may be a treatment for schizophrenia

by amanda alvarez | Hot Off the Press

Supplementing model mice with glycine betaine (trimethylglycine), a compound originally derived from beets, can alleviate symptoms of schizophrenia.

Jun

Gray matter volume links symptoms in autism

by adam phillips | Hot Off the Press

Low gray matter volume in the posterior superior parietal lobule (pSPL) was found to correlate with specific cognitive and perceptual symptoms of autism.

Jun

New mechanism allows lower energy requirement for OLED displays

by jens wilkinson | Hot Off the Press

Scientists have found a way to significantly reduce the amount of energy required by organic light emitting diodes (OLED) displays.

Jun

CAPON links Alzheimer’s plaques to neurodegeneration

by adam phillips | Hot Off the Press

CAPON was found to link Aβ plaques and hippocampal neurodegeneration in mice, explaining how these two hallmarks of Alzheimer’s disease are related.

May

AdR blockers protect the brain from stroke damage

by amanda alvarez | Hot Off the Press

Treatment with adrenergic receptor antagonists (AdR blockers) was able to reduce stroke-related brain damage in mice and improve motor recovery.

Apr

Trigger region found for epileptic absence seizures

by adam phillips | Hot Off the Press

A mouse model shows that absence seizures are triggered by faulty connections between the cortex and fast-spiking neurons in the striatum.

Introducing Nikola, the emotional android boy

A new android named Nikola will help researchers study facial expressions, emotions, and social interactions.

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Social contact-seeking behavior and loneliness in the brain

Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

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H2AK119ub1: How you inherit acquired traits from your mom

H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.

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Eating a high fat diet without getting obese?

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Read on

May

Dietary amino acid linked to cancer in flies

by masataka sasabe | Hot Off the Press

Researchers have found a dietary amino acid linked to oncogene expression / tumor formation; reduced consumption reduced cancer in flies.

Apr

Cancer cells killed with artificial glycosylated metalloenzyme

by adam phillips | Hot Off the Press

Scientists have developed two cancer therapies that use an artificial glycosylated metalloenzyme to specifically target cancer cells in mice.

Apr

H2AK119ub1: How you inherit acquired traits from your mom

by adam phillips | Featured, Hot Off the Press

H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.

Apr

COVID-19: Changing the way we do research

by jens wilkinson | Interviews

COVID-19 series — Part #4: Team Leader Aki Minoda from RIKEN IMS talks about how the pandemic has affected the way we work.

Mar

Telework: a societal game-changer

by jens wilkinson | Interviews

COVID-19 series — installment #3: Team Leader Osamu Sakura (@RIKEN Center for Advanced Intelligence Project) talks about how the pandemic has affected society through the need for telework.