Atlas of the aging lipidome highlights kidneys and gut bacteria


The atlas revealed sex differences in the aging kidney lipidome and lipid byproducts of gut bacteria that accumulate throughout the body.

Why (mouse) mothers take risks to protect their infants


The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.

Eating a high fat diet without getting obese?


Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Understanding non-coding DNA: gene “enhancers”


NETCAGE is a newly developed technique for determining the structure of portions of the non-coding genome called ‘enhancers.’

Low-protein diet changes sperm and health of future offspring


Low-protein diets in male mice alter sperm and result in offspring that have metabolic problems like diabetes in adulthood.

Mutations, CRISPR, and spinocerebellar ataxia


Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

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Confronting a string of epidemics including COVID-19


COVID-19 series — installment #1: RIKEN Executive Director Shigeo Koyasu talks about epidemics and what a good response looks like.

Omics Omics Omics: Analysis predicts ovarian cancer-treating drug


Multi-omics analysis prediction: drugs that inhibit Ras signaling will help prevent tumor formation in serous ovarian cancer.

Diagnosing fetal heart disease benefits from explanatory AI


Diagnosis accuracy improved when doctors used explanatory AI to help diagnose congenital heart disease from fetal ultrasound videos.

Evolution of the inner ear: insights from jawless fish


A new story for inner ear evolution based on the developmental patterning found in hagfish, one of two extant jawless vertebrates and a link to the last common ancestor of modern jawed vertebrates.

Toward human hibernation: cold-resistant mouse stem cells


Cold-resistant stem cells from “deep torpor” mice are a big step toward understanding why tissue survives hibernation.

Massive filaments, galaxies, and supermassive black holes


Big telescopes yield big data! Detailed observations gas filaments connecting galaxies in a distant proto-cluster in the early Universe.

Next stop: clinical hair regeneration


A new recipe for continuous cyclical hair regeneration in mice. This means that the hair will continue to fall out and regrow like normal hair.

New treatment assembles cancer drug inside the body


Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

Social contact-seeking behavior and loneliness in the brain


Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

New lab-grown retinal sheets almost ready for clinical trials


A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.