Sphingolipid S1P: Potential new target for schizophrenia treatment

Sphingolipid S1P is reduced in brain white matter of people with schizophrenia, making S1P receptors a good target for new treatments.
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Organ regeneration in the lab

Interview with Takashi Tsuji, team leader of the Laboratory for Organ Regeneration at the RIKEN Center for Developmental Biology

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Why (mouse) mothers take risks to protect their infants

The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.
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A new and improved way to store hydrogen

A simple chemical reaction allows hydrogen-carrying ammonia to be stored and retrieved cheaply and easily.
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Dopamine reduces beta-amyloid plaques in Alzheimer’s disease

Increasing dopamine in the brains of AD model mice led to increased neprilysin, which broke down amyloid-beta plaques and improved memory.
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Toward human hibernation: cold-resistant mouse stem cells

Cold-resistant stem cells from “deep torpor” mice are a big step toward understanding why tissue survives hibernation.
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RIKEN Research Spring issue is here

Just a quick post to let you know that the Spring issue of RIKEN Research Magazine came out towards the end of March. This issue covers issues including the discovery of element 113, earth-friendly pesticides, and the secrets of a rice-killing fungal toxin. Enjoy!

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Cubes of brain tissue allow drug discovery without animals

Modeling the blood-brain-barrier with brains-in-a-cube allows drug testing without the need for animals.
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CAPON links Alzheimer’s plaques to neurodegeneration

CAPON was found to link Aβ plaques and hippocampal neurodegeneration in mice, explaining how these two hallmarks of Alzheimer’s disease are related.

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Cancer cells killed with artificial glycosylated metalloenzyme

Scientists have developed two cancer therapies that use an artificial glycosylated metalloenzyme to specifically target cancer cells in mice.
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Super-thin wearable electronics just got more flexible

A method for making super-flexible and ultra-thin wearable electronics uses water-vapor plasma to create gold-gold bonds.
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Telework: a societal game-changer

COVID-19 series — installment #3: Team Leader Osamu Sakura (@RIKEN Center for Advanced Intelligence Project) talks about how the pandemic has affected society through the need for telework.
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Opossums are the first genome edited marsupials

A new piezoelectronic microinjection method has allowed the first successful genome editing in marsupials: albino opossums.
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New lab-grown retinal sheets almost ready for clinical trials

A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.
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Artificial gravity protects the immune system of mice in space

Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.
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Eating a high fat diet without getting obese?

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.
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