Brain wave synchrony can predict memory age


The degree of neuronal synchrony between the anterior cingulate cortex and the hippocampus during recall is an indication of memory age (in mice).

RIKEN at a glance


We’ve just gotten our order of RIKEN at a Glance booklets back from the printers, and they look fantastic. Follow the link to download your electronic copy now!

Mutations, CRISPR, and spinocerebellar ataxia


Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

Understanding non-coding DNA: gene “enhancers”


NETCAGE is a newly developed technique for determining the structure of portions of the non-coding genome called ‘enhancers.’

Microcolumns: elementary neuronal units that carpet the (mouse) brain


A hexagonal lattice organizes major cell types in the cerebral cortex, with similar cells synchronizing their activity in microcolumns.

Schizophrenia biomarker (hydrogen sulfide) in human hair


Not only is hydrogen sulfide a good biomarker for schizophrenia, it’s also the culprit and a new starting point for drug discovery.

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Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

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New treatment assembles cancer drug inside the body


Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

Skipping fatty acids could be recipe for schizophrenia


Prenatal lack of omega-3 and omega-6 fatty acids linked to epigenetic changes that lead to schizophrenic symptoms in mice.

Melatonin in mice, circadian rhythms, and daily torpor


A new breed of lab mouse allows the study of naturally occurring melatonin. These mice will adjust better to jetlag than regular lab mice and experience daily torpor.

Two genes that regulate how much we dream


An international research team led by RIKEN BDR has identified a pair of genes that regulate how much REM (dream) and non-REM sleep an animal experiences.

Gut bacteria double team worsens symptoms of multiple sclerosis


Joint activity of two gut bacteria leads to excessive MOG-specific T-cell activity and demyelination of neurons in the spinal cord of a mouse model of multiple sclerosis.

Dopamine reduces beta-amyloid plaques in Alzheimer’s disease


Increasing dopamine in the brains of AD model mice led to increased neprilysin, which broke down amyloid-beta plaques and improved memory.

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Artificial gravity protects the immune system of mice in space


Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.

Eating a high fat diet without getting obese?


Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

New treatment assembles cancer drug inside the body


Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

H2AK119ub1: How you inherit acquired traits from your mom


H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.