Award-winning 3D images of living cells


An interview with Yuko Kiyosue, discussing the 3D images of living cells that gained her and her colleagues a recent award.

Chromosome copying errors pinpointed in developing embryos


The DNA duplication process changes during embryogenesis and chromosome copying errors increase during the transition.

Genomic “butterfly effect” involving TADs explains risk for autism


De novo mutations in three-dimensional structures in the genome containing known ASD genes were found to be associated with ASD risk.

Melatonin in mice, circadian rhythms, and daily torpor


A new breed of lab mouse allows the study of naturally occurring melatonin. These mice will adjust better to jetlag than regular lab mice and experience daily torpor.

Blood cell mutations linked to leukemia are inevitable


Researchers show that blood cell mutations increase with age identify risk factors for developing leukemia in Japanese and European populations.

Something smells fishy: categorizing odors in the brain


Calcium imaging and mathematical model explain how categories and mixtures of odors are represented in the fly brain and consistent across individual flies.

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Hippocampal memory isn’t all about place cells


Scientists have found evidence that hippocampal memories of experience are not stored in place cells.

Running away from carbon dioxide: the terminal connection


Even fish want to avoid carbon dioxide. Now we know that they can because of chemosensation and the Terminal Nerve.

Mutations, CRISPR, and spinocerebellar ataxia


Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

The brain’s GPS has a buddy system


In addition to encoding self location, brain cells in the rat hippocampus act like a GPS that encodes the location of other rats.

Mathematical model predicts self-organized learning in real neurons


The free energy principle predicted how real neural connections changed as neurons “learned” in a dish.

Kleefstra syndrome in mice reversed after birth


Researchers used a postnatal supply of GLP to reverse neural and behavioral symptoms of Kleefstra syndrome in mice!

H2AK119ub1: How you inherit acquired traits from your mom


H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.

Social contact-seeking behavior and loneliness in the brain


Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.

Eating a high fat diet without getting obese?


Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Why (mouse) mothers take risks to protect their infants


The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.