Centennial RIKEN Research

???This Spring we’ve put together a special centennial issue of RIKEN Research ???

New metalloenzyme system selectively targets cancer cells

Specific targeting of cancer cells and onsite drug synthesis has been achieved using a new artificial metalloenzyme delivery system.

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Fall is here, and with it comes the latest issue of RIKEN Research. This issue covers tactile learning during sleep, supercomputers and simulations, solar cells, fly olfaction, tumor vaccines, and more

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Physiological origami and proper body development in flies

Genetics and mechanical origami in the fly embryo helps proper body development by fighting off “noisy” fluctuations is the environment.

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Mutation links bipolar disorder to mitochondrial disease

ANT1 mutations found in bipolar disease that affect mitochondria lead to hyperexcitable serotonergic neuronal activity in the brain.

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New treatment assembles cancer drug inside the body

Cancer drugs assembled inside the body on cancer cells should reduce harmful side effects to other tissue.

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Topics

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Astrocytes powered by norepinephrine during fear-memory formation

Norepinephrine released in the locus coeruleus during fear learning is accompanied by increased calcium and cAMP levels in nearby astrocytes.

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Low-protein diet changes sperm and health of future offspring

Low-protein diets in male mice alter sperm and result in offspring that have metabolic problems like diabetes in adulthood.

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Cyborg microchip valve driven by earthworm muscle

This earthworm muscle-controlled biological microelectromechanical system (bio‐MEMS) could lead the way to next-generation medical implants.

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Random movements help color-detecting cells form the proper pattern

Scientists have used a mathematical model to explain why zebrafish cone cells in the eye are arranged in a specific pattern in all individuals.

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Geostationary satellite enables better precipitation and flood predictions

Data from the Himawari-8 geosynchronous satellite was used in weather simulations to improve forecasts of sudden precipitation and tropical storm development.

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The joys of computational mass spectrometry

Scientists have developed a new automated computational mass spectrometry system that can search an organism’s entire metabolome for as-yet-unknown metabolites (potential drugs).

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Dec

Supermassive black holes still dark and mysterious

by jens wilkinson | Hot Off the Press

For the first time, scientists have measured the strength of magnetic fields near supermassive black holes and something doesn’t add up.

Dec

Evolution of the inner ear: insights from jawless fish

by adam phillips | Hot Off the Press

A new story for inner ear evolution based on the developmental patterning found in hagfish, one of two extant jawless vertebrates and a link to the last common ancestor of modern jawed vertebrates.

Dec

Tumor detection during breast cancer surgery

by jens wilkinson | Hot Off the Press

Scientists have developed a new way to accurately detect the margins between cancerous and non-cancerous tissue during breast cancer surgery.

Nov

Smarter AI: machine learning without negative data

by masataka sasabe | Hot Off the Press

Scientists have developed a new method for machine learning that allows an AI to make better classifications without negative data.

Nov

Nerdnite recap: When the brainbow met the boson

by amanda alvarez | Drop of science

Fun times at nerdnite tokyo. Brains, bosons, and math, oh my!

Nov

Mutations, CRISPR, and spinocerebellar ataxia

by adam phillips | Hot Off the Press

Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

Nov

Gene regulator that allows plant rehydration after drought

by adam phillips | Hot Off the Press

New genetic insights into the plant rehydration process: this is why your plants don’t die after you forgot to water them.

Oct

Researchers create a functional salivary gland organoid ?

by jens wilkinson | Hot Off the Press

Scientists have succeeded in growing three-dimensional salivary gland tissue that produced saliva like normal glands when implanted into mice.

Oct

Getting a grip on slow but unique shark evolution

by masataka sasabe | Hot Off the Press

Scientists have decoded the genomes of two species of shark, bringing the grand total of sequenced shark genomes to three.

Introducing Nikola, the emotional android boy

A new android named Nikola will help researchers study facial expressions, emotions, and social interactions.

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Talking science Illustration with Misaki Ouchida

Whether it’s bird anatomy or science cartoons, Masaki Ouchida can do it all. She spoke with us about her career in science illustration, from the US to Japan.

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Green hydrogen production for fuel cells and fertilizers

A new method of water electrolysis avoids rare metals, making hydrogen production green and sustainable.

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Social contact-seeking behavior and loneliness in the brain

Levels of the peptide amylin in the brain are related to loneliness; activating amylin neurons in the MPOA drives isolated mice to seek social contact.