Cubes of brain tissue allow drug discovery without animals

Modeling the blood-brain-barrier with brains-in-a-cube allows drug testing without the need for animals.
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Xist knockout rescues miscarriages in mice

Xist knockout rescues miscarriages in mice whose egg cells lack H3K27me3 epigenetic instructions.
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Confronting a string of epidemics including COVID-19

COVID-19 series — installment #1: RIKEN Executive Director Shigeo Koyasu talks about epidemics and what a good response looks like.
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Mutations, CRISPR, and spinocerebellar ataxia

Scientists discover that mutations causing the degenerative movement disorder spinocerebellar ataxia type 29 work by disrupting calcium release of neurons inside the brain.

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Godzilla-sized zooplankton for better aquafarming

Scientists have created extra large zooplankton to help feed the fish in aquafarms. The new plankton were created using an ion beam to generate mutations.
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Opossums are the first genome edited marsupials

A new piezoelectronic microinjection method has allowed the first successful genome editing in marsupials: albino opossums.
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Xist knockout rescues miscarriages in mice

Xist knockout rescues miscarriages in mice whose egg cells lack H3K27me3 epigenetic instructions.
Read on

Why (mouse) mothers take risks to protect their infants

The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.
Read on

AI identifies features associated with cancer recurrence

Artificial intelligence has successfully identified features relevant to cancer prognosis that were not previously noted by pathologists
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A researcher’s journey: from surfing to studying pain

Joshua Johansen from RIKEN CBS tells us about his journey from surfer to pain researcher and beyond. Stay tuned for part II …
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New artificial skin helps avoid animal testing

A new artificial skin that reproduces proper tension can be used to research skin function and disease while reducing the need to experiment on animals.
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Cassava engineered to produce healthier tapioca starch

Reducing the amount of starch branching enzymes in cassava plants made more resistant and thus healthier tapioca starch.
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New lab-grown retinal sheets almost ready for clinical trials

A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.
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H2AK119ub1: How you inherit acquired traits from your mom

H2AK119ub1. Say that three times really fast! But seriously, it allows maternally acquired traits to be inherited.
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Transgenic plants ??on acid survive without water

Scientists designed transgenic plants that survive drought-like conditions by bumping up acetic acid production only when water is scarce.

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Why (mouse) mothers take risks to protect their infants

The calcitonin receptor and its ligand amylin act in the brain to motivate mouse mothers to protect their pups, even in risky/dangerous situations.
Read on