The It Ain't Magic Science Blog

Xist knockout rescues miscarriages in mice

Xist knockout rescues miscarriages in mice whose egg cells lack H3K27me3 epigenetic instructions.

Evolution of the inner ear: insights from jawless fish

A new story for inner ear evolution based on the developmental patterning found in hagfish, one of two extant jawless vertebrates and a link to the last common ancestor of modern jawed vertebrates.

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Palaeospondylus: mystery of vertebrate evolution solved

Micro-CT scans using synchrotron radiation X-rays reveal Palaeospondylus morphology, finally allowing its placement on the evolutionary tree.

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A new and improved way to store hydrogen

A simple chemical reaction allows hydrogen-carrying ammonia to be stored and retrieved cheaply and easily.

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RIKEN discovers new T cells related to immune disorders

Immune-related diseases like multiple sclerosis associated with genetic variation in newly discovered, rare T cells.

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Dopamine reduces beta-amyloid plaques in Alzheimer’s disease

Increasing dopamine in the brains of AD model mice led to increased neprilysin, which broke down amyloid-beta plaques and improved memory.

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Self-assembly of spider silk

This gut microbe might protect against diabetes and reduce insulin resistance

NEW: One-way hydrogel guides motion of tiny worms!

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Millions of years of galaxy evolution simulated in mere months with the help of AI

When a machine learning AI was asked to help simulate galaxy evolution, processing time went from years to months.

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Leaky plants bad for drought resistance

The KAI2 receptor for compounds found in smoke helps plants retain water and survive during drought.

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The first drug treatment for brain aneurysms (in mice)

Scientists discover that most aneurysms result from mutations. A mouse model shows they can be treated with drugs.

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New lab-grown retinal sheets almost ready for clinical trials

A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.

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Getting a grip on slow but unique shark evolution

Scientists have decoded the genomes of two species of shark, bringing the grand total of sequenced shark genomes to three.

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AI identifies features associated with cancer recurrence

Artificial intelligence has successfully identified features relevant to cancer prognosis that were not previously noted by pathologists

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Jul

Cyborg microchip valve driven by earthworm muscle

by adam phillips | Hot Off the Press

This earthworm muscle-controlled biological microelectromechanical system (bio‐MEMS) could lead the way to next-generation medical implants.

Jul

Eating a high fat diet without getting obese?

by adam phillips | Featured, Hot Off the Press

Scientists discover that without innate immune cells in the intestines, eating a high fat diet does not lead to obesity in mice.

Jul

New metalloenzyme system selectively targets cancer cells

by masataka sasabe | Hot Off the Press

Specific targeting of cancer cells and onsite drug synthesis has been achieved using a new artificial metalloenzyme delivery system.

Jun

Boosting betaine may be a treatment for schizophrenia

by admin | Hot Off the Press

Supplementing model mice with glycine betaine (trimethylglycine), a compound originally derived from beets, can alleviate symptoms of schizophrenia.

Jun

Gray matter volume links symptoms in autism

by adam phillips | Hot Off the Press

Low gray matter volume in the posterior superior parietal lobule (pSPL) was found to correlate with specific cognitive and perceptual symptoms of autism.

Jun

New mechanism allows lower energy requirement for OLED displays

by jens wilkinson | Hot Off the Press

Scientists have found a way to significantly reduce the amount of energy required by organic light emitting diodes (OLED) displays.

Jun

CAPON links Alzheimer’s plaques to neurodegeneration

by adam phillips | Hot Off the Press

CAPON was found to link Aβ plaques and hippocampal neurodegeneration in mice, explaining how these two hallmarks of Alzheimer’s disease are related.

May

AdR blockers protect the brain from stroke damage

by admin | Hot Off the Press

Treatment with adrenergic receptor antagonists (AdR blockers) was able to reduce stroke-related brain damage in mice and improve motor recovery.

Apr

Trigger region found for epileptic absence seizures

by adam phillips | Hot Off the Press

A mouse model shows that absence seizures are triggered by faulty connections between the cortex and fast-spiking neurons in the striatum.

Diazoxide pills for Alzheimer’s disease?

Drug therapy with with diazoxide relieved symptoms of Alzheimer’s disease in the brains of mice and improved memory.

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Artificial gravity protects the immune system of mice in space

Mice who experienced artificial gravity on the ISS suffered less damage to their immune system (thymus) than weightless mice did.

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New lab-grown retinal sheets almost ready for clinical trials

A new retinal transplant technique works by preventing bipolar cells from maturing in lab-grown retinal sheets.

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Green hydrogen production for fuel cells and fertilizers

A new method of water electrolysis avoids rare metals, making hydrogen production green and sustainable.

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Jul

Methylation mutation directly linked to autism

by adam phillips | Hot Off the Press

A mutation in a gene needed for H3K9 methylation is directly linked to autism spectrum disorders and early neurodevelopment.

Jun

Melatonin in mice, circadian rhythms, and daily torpor

by admin | Hot Off the Press

A new breed of lab mouse allows the study of naturally occurring melatonin. These mice will adjust better to jetlag than regular lab mice and experience daily torpor.